aao TCA yaad karein

TCA cycle:

1.pyruvate+ CoA+NAD+ -> acetyl CoA+co2+NADH

pyruvate dehydrogenase


E1:pyruvate dehydrogenase complex,TPP(thiamine pyrophosphate),oxidative decarboxlation of pyruvate.

E2:dihyroxylipoyl transacetylase,lipoamide,tranfer of acetly to CoA.

E3:dihyroxy lipoyl dehyrogenase,FAD,regeneration of oxidized lipoamide.


place:the playing ground

E1:badminton court

paru is waiting with hydrogen cylinders tied to his back.he's playing badminton,peeche se bharoon aake kehta hai...TaPPu!paru gives himthis-is-badminton-not-basketball-looks.

E2:tennis court
2 botal paani(1 on each pole of the net) aur ek lolipop(in the centre of the net) padi hai tennis court mein.
dihyroxy lipoly

aur phir bobby darling with acetic acid aati hai,to play tennis.
transacetylase.

E3:basketball court
dihyroxy lipoyl dehydrogenase.


simply:decarb->transfer of acetyl->lipoyl ki marammat by hydrogen to FAD,then to NAD.


2.the cycle:

from:lt3->boys lu->generator waali jagah->mandir->fountain->buletin board->uniform shop->photcopy place

lt3:citrate,synthase.

entry of LT2 turned into a huge citrus fruit,orange ya lemon.
aur lemon ke bagal mein,synth par,bahut tez tez moozic baja raha hai.(synthase)

boys lu:isocitrate,acotinase

me sleeping in the boys room(i so).
with me is Acon,wohi gande gaane gaane waala.

generator room:alpha keto glutarate,dehydrogenase

since the generator waali jagah is undergound,as you open its door,bahoot saare keet makoode slam into your face.aur tum neeche jhank ke dekte ho..you see a lot of water in it.(hydro)

madir:succinyl CoA,dehydrogenase

mandir mein prashad mein sabko lolipop milti hai to suck.
of course,yahn bhi dhaer saara paani hai.that has come from a well(kuan)(CoA)

Fountain:succinate,sythetase

fountain pe nate log(dg,beeps and riccha) are eating a lolipop.(succinate)

peehce background music for this grand event is being done by bharoon standing insde the fountain,on sythesizer,teasing all of them.

buletin board:fumerate,dehydrogenase

bultein board pe bahut saare logon ko crucify kara gaya hai,but unmein se sirf kuch(few) hi mare hain.

and you revve the survivors using water(dehydrogenase)

uniform shop:malate,fumarase

a few people are counting money(maal) outside the uniform shop.
unme se kuch,mar jaate hain.ginte ginte.

photocopy shop:oxaloacetate,dehydrogenase

photocopy waale bhaiya ke pass,ek bael(ox) khadi hai.
aur woh usko paani pilaane ko aapko bol rahe hain.


Regulation:

1.at pyruvate dehydrogenase.

swithed off when energy charge is high

- acetyl CoA,ATP,NADH activate kinase.
+ ADP,Pyruvate,,NAD+(deactivate kinase) Ca2+ activate phosphatase.


2.Isocitrate dehydrogenase
+ADP
-ATP,NADH

3.Alpha keto glutarate
-succinyl coa,NADH,ATP

Arsenite poisoning
arsenite ind to e2.
BAL(2,3 dimercaptopropanol)(23(neem)DMP)(dimpy naam ki ladki) used to relieve the arsenite.


glyoxylate cyle
Acetate+CoASH+ATP->Acetly CoA+AMP+ppi

cit->isocit->glyoxylate->malate->OAA->cit
acotinase,isocitrate lysase,matale synthase,malate dehydrogenase,citrate synthase